Fekete, Tünde and Bencze, Dóra and Bíró, Eduárd and Benkő, Szilvia and Pázmándi, Kitti Linda (2021) Focusing on the Cell Type Specific Regulatory Actions of NLRX1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (3). pp. 1-36. ISSN 1661-6596
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Abstract
Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect exogenous or endogenous danger signals and even the changes of their microenvironment. However, some cytosolic NOD-like receptors (NLR), including NLRX1, serve more functions than just being general pattern recognition receptors. The dynamic translocation between the cytosol and the mito-chondria allows NLRX1 to interact with many molecules and thereby to control multiple cellular functions. As a regulatory NLR, NLRX1 fine-tunes inflammatory signaling cascades, regulates mi-tochondria-associated functions, and controls metabolism, autophagy and cell death. Nevertheless, literature data are inconsistent and often contradictory regarding its effects on individual cellular functions. One plausible explanation might be that the regulatory effects of NLRX1 are highly cell type specific and the features of NLRX1 mediated regulation might be determined by the unique functional activity or metabolic profile of the given cell type. Here we review the cell type specific actions of NLRX1 with a special focus on cells of the immune system. NLRX1 has already emerged as a potential therapeutic target in numerous immune-related diseases, thus we aim to highlight which regulatory properties of NLRX1 are manifested in disease-associated dominant immune cells that presumably offer promising therapeutic solutions to treat these disorders. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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| Additional Information: | Department of Immunology, Faculty of Medicine, University of Debrecen, 1 Egyetem Square, Debrecen, H-4032, Hungary Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, 1 Egyetem Square, Debrecen, H-4032, Hungary Department of Physiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei krt., Debrecen, H-4002, Hungary Export Date: 23 March 2021 Correspondence Address: Pázmándi, K.; Department of Immunology, 1 Egyetem Square, Hungary; email: pazmandikitti@yahoo.de Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, FEDER Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, FK 128294, GINOP-2.3.2-15-2016-00050, K 131844, PD 135193 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Ministry for Innovation and Technology Funding details: National Research, Development and Innovation Office Funding text 1: This work was supported by the National Research, Development and Innovation Office (NKFIH FK 128294 to KP, NKFIH PD 135193 to TF and NKFIH K 131844 to SB). The work was also supported by GINOP-2.3.2-15-2016-00050 project. The project is co-financed by the European Union and the European Regional Development Fund. KP was also supported by ?NKP-20-05-DE-3 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund and the J?nos Bolyai Research Scholarship from the Hungarian Academy of Sciences. |
| Uncontrolled Keywords: | Metabolism; Mitochondria; Regulation; immune cells; Autophagy; MYELOID CELLS; NF-κB pathway; lymphoid cells; NLRX1; Antiviral immunity; |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 28 Sep 2021 21:23 |
| Last Modified: | 28 Sep 2021 21:23 |
| URI: | http://real.mtak.hu/id/eprint/131249 |
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