Genome Sequencing of a Novel Variant of Fowl Adenovirus B Reveals Mosaicism in the Pattern of Homologous Recombination Events

Homonnay, Zalán and Jakab, Szilvia and Bali, Krisztina and Kaszab, Eszter and Mató, Tamás and Kiss, István and Palya, Vilmos and Bányai, Krisztián (2021) Genome Sequencing of a Novel Variant of Fowl Adenovirus B Reveals Mosaicism in the Pattern of Homologous Recombination Events. ARCHIVES OF VIROLOGY : OFFICIAL JOURNAL OF THE VIROLOGY DIVISION OF THE INTERNATIONAL UNION OF MICROBIOLOGICAL SOCIETIES, 166 (5). pp. 1477-1480. ISSN 0304-8608 (print); 1432-8798 (online)

Text Homonnay2021_Article_GenomeSequencingOfANovelVarian.pdf - Published Version Restricted to Repository staff only Download (1MB)

Abstract

We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species.

Actions (login required)

Edit Item