Horkay, Ferenc and Szokodi, István and Selmeci, L. and Merkely, Béla Péter and Kékesi, Violetta and Tóth, Miklós (1998) Presence of immunoreactive endothelin-1 and atrial natriuretic peptide in human pericardial fluid. LIFE SCIENCES, 62 (3). pp. 267-274. ISSN 0024-3205
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Abstract
This study was undertaken to characterize endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) concentrations in human pericardial fluid, blood plasma, right atrial appendage and papillary muscle by use of specific radioimmunoassays. In patients undergoing cardiac surgery (n=16) pericardial fluid mean immunoreactive (ir-) ET-1 and ir-ANP levels were 36-fold and 4-fold higher than corresponding plasma levels, respectively. In high performance liquid chromatography (HPLC) pericardial fluid ir-ET-1 was indistinguishable from human ET-1[1-21] and the majority of pericardial fluid ir-ANP coeluted with human ANP[99-126]. Atrial tissue ir-ET-1 and ir-ANP concentrations were 17-fold and 870-fold higher than in ventricular tissue. Our present study demonstrated for the first time the presence of ir-ET-1 in the pericardial fluid in humans. Human pericardial fluid contained far the highest concentrations of ET-1 among all biological fluids tested thus far. The functions of pericardial fluid ET-1 and ANP on cardiac performance and coronary vascular tone require further investigations.
Item Type: | Article |
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Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 31 Jul 2014 15:23 |
Last Modified: | 31 Jul 2014 15:23 |
URI: | http://real.mtak.hu/id/eprint/14033 |
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