Benke, Edit and Szabó-Révész, Piroska and Ambrus, Rita (2021) Development of meloxicam potassium-containing co-spray-dried inhalation powder with sodium stearate. ACTA PHARMACEUTICA HUNGARICA, 91 (2). pp. 75-82. ISSN 0001-6659
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Abstract
Pulmonary drug delivery (PDD) has potential for both local and systemic therapy. Our research group is focus- ing on the development of dry powder inhalation (DPI) systems for PDD due to their beneficial properties. Although there is not yet a marketed inhalation product for non-steroidal anti-inflammatory drugs (NSAIDs), their therapeutic use in sev- eral lung diseases is well established and successful DPI developments have been performed with them. Sodium stearate (NaSt) is a promising excipient for DPI development, but its role in NSAIDs has not yet been investigated. Thus, the aim was to study DPI samples produced by co-spray-drying, applying meloxicam potassium (MXP) as an NSAID drug, and different concentrations (0-2 w/w%) of NaSt. Physicochemical investigations, in vitro lung deposition, and in vitro drug release measurements were performed. It can be stated that co-spray-drying of MXP with NaSt resulted in remarkable morphological differences by increasing the concentration of NaSt, which had a positive effect on cohesive work. Further- more, applying of NaSt accelerates the dissolution in simulated lung fluid (SLF). NaSt as excipient has a future for the formulation of the DPI systems because there are in the development focus the attaintment of the higher FPF values and improvement of dissolution in SLF.
Item Type: | Article |
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Subjects: | R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan |
SWORD Depositor: | MTMT SWORD |
Depositing User: | Zsolt Baráth |
Date Deposited: | 13 May 2022 09:02 |
Last Modified: | 13 May 2022 09:02 |
URI: | http://real.mtak.hu/id/eprint/142741 |
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