Fekete, Mónika and Szőllősi, Gergő József and Tarantini, Stefano and Lehoczki, Andrea and Németh, Anna Noémi and Bodola, Csenge and Varga, Luca and Varga, János Tamás (2022) Metabolic syndrome in patients with COPD: causes and pathophysiological consequences. Physiology International, 109 (1). pp. 90-105. ISSN 2498-602X
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Abstract
Background: Decreased physical activity significantly increases the probability of prevalent metabolic syndrome (MetS) with substantial impact on the expected course of COPD. Objective: Our research aims to assess the metabolic consequences of chronic obstructive pulmonary disease (COPD) and evaluate the prevalence of MetS and its interrelations with age, sex, comorbidities, drug intake, degree of decreased lung function, nutritional status, physical activity and quality of life. Methods: A cross-sectional study was performed on a random sample (n = 401) at the Department of Pulmonary Rehabilitation of the National Koranyi Institute of Pulmonology from March 1, 2019 to March 1, 2020 in Budapest, Hungary. Anthropometric and respiratory function tests and laboratory parameters of all patients were registered. Results: MetS occurred in 59.1% of COPD patients with significant gender difference (male: 49.7% female: 67.6%). Concerning BMI, the prevalence of MetS was higher with BMI >= 25 kg m(-2) (P < 0.0001). Patients with this syndrome had significantly worse FEV1%pred (43 (30-56) vs. 47 (36-61); P = 0.028), lower quality of life (CAT: 26 (21-32) vs. 24.5 (19-29); P = 0.049) and significantly more frequent exacerbations (2 (1-3) vs.1 (0-2); P < 0.05), than patients without MetS. The prevalence of comorbidities were higher in overweight/obese patients (BMI> 25 kg m(-2)). Conclusions: In COPD patients MetS negatively affect respiratory function and quality of life and promotes exacerbations of the disease. MetS is related to nutritional status and the level of systemic inflammation in COPD patients.
| Item Type: | Article |
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| Additional Information: | Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Family and Occupational Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73132, United States National Institute for Haematology and Infectious Diseases, Department of Haematology and Stem Cell Transplantation, South Pest Central Hospital, Budapest, Hungary Department of Pulmonology, Semmelweis University, Budapest, Hungary Export Date: 12 May 2022 Correspondence Address: Varga, J.T.; Department of Pulmonology, Hungary; email: varga.janos_tamas@med.semmelweis-univ.hu Chemicals/CAS: C reactive protein, 9007-41-4 |
| Uncontrolled Keywords: | PREVALENCE; metabolic syndrome; chronic obstructive pulmonary disease; EXACERBATIONS; inflammation.; |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 29 Jun 2022 13:02 |
| Last Modified: | 29 Jun 2022 13:02 |
| URI: | http://real.mtak.hu/id/eprint/144276 |
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