The other side of the coin : Functional and structural versatility of ADF/cofilins

Hild, Gábor and Kalmár, Lajos and Kardos, Roland and Nyitrai, Miklós and Bugyi, Beáta (2014) The other side of the coin : Functional and structural versatility of ADF/cofilins. European Journal of Cell Biology, 93 (5-6). pp. 238-251. ISSN 0171-9335

Preview

Text Hild et al EJCB accepted ms_figures.pdf Download (2MB) | Preview

Abstract

Several cellular processes rely on the fine tuning of actin cytoskeleton. A central component in the regulation of this cellular machinery is the ADF-H domain proteins. Despite sharing the same domain, ADF-H domain proteins produce a diverse functional landscape in the regulation of the actin cytoskeleton. Recent findings emphasize that the functional and structural features of these proteins can differ not only between ADF-H families but even within the same family. The structural and evolutional background of this functional diversity is poorly understood. This review focuses on the specific functional characteristics of ADF-H domain proteins and how these features can be linked to structural differences in the ADF-H domain and also to different conformational transitions in actin. In the light of recent discoveries we pay special attention to the ADF/cofilin proteins to find tendencies along which the functional and structural diversification is governed through the evolution.

Actions (login required)

Edit Item