Ozger, Hasan Selcuk and Evren, Ebru and Yildiz, Serap Suzuk and Erol, Cigdem and Bayrakdar, Fatma and Azap, Ozlem and Azap, Alpay and Senol, Esin (2021) Ceftazidime - Avibactam susceptibility among carbapenem-resistant Enterobacterales in a pilot study in Turkey. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 68 (4). pp. 256-261. ISSN 1217-8950
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Abstract
This study aimed to detect carbapenemase genes and to determine the in vitro susceptibility of Ceftazidime-Avibactam (CZA) in Enterobacterales isolates. Carbapenemase genes were detected by polymerase chain reaction. CZA sensitivity of isolates was evaluated with broth microdilution (BMD) and disk diffusion methods. A total of 318 carbapenem-resistant Enterobacterales isolates were included. Most of the isolates (n = 290, 91.2%) were identified as Klebsiella pneumoniae. The most common carbapenemase type was OXA-48 (n = 82, 27.6%). CZA susceptibility was evaluated in 84 isolates with OXA-48 and KPC carbapenemase activity. Both BMD and disk diffusion methods revealed that 95.2% of the isolates were sensitive to CZA; whereas, 4 (4.76%) isolates were resistant to CZA. Among colistin resistant isolates, 96.5% (n = 80) of them were susceptible to CZA. Our study demonstrated high in vitro efficacy of CZA in Enterobacterales isolates producing OXA-48 carbapenemase. High susceptibility rates against colistin resistant isolates which generally are also pan drug resistant, makes CZA a promising therapeutic choice for difficult-to-treat infections. Due to its high correlation with the BMD, disk diffusion method is a suitable and more practical method in detecting CZA in vitro activity.
Item Type: | Article |
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Additional Information: | Funding Agency and Grant Number: Turkish Association of Clinical Microbiology and Infectious Diseases; Pfizer A.SPfizer [56563383] Funding text: This work was supported by Turkish Association of Clinical Microbiology and Infectious Diseases with an independent grant support from Pfizer A.S. |
Uncontrolled Keywords: | ESCHERICHIA-COLI; immunology; EPIDEMIOLOGY; KLEBSIELLA-PNEUMONIAE; carbapenemase; colistin; Ceftazidime-avibactam; |
Subjects: | Q Science / természettudomány > QR Microbiology / mikrobiológia |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 20 Jul 2022 06:39 |
Last Modified: | 31 Dec 2022 00:16 |
URI: | http://real.mtak.hu/id/eprint/144968 |
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