Fertőzésekhez kapcsolódó immunológiai jelenségek: a szürkezóna jelentősége = Immunologic complications of infections: the relevance of the grey zone

Zóka, András and Kádár, Béla and Vad, Eszter (2021) Fertőzésekhez kapcsolódó immunológiai jelenségek: a szürkezóna jelentősége = Immunologic complications of infections: the relevance of the grey zone. ORVOSI HETILAP, 162 (38). pp. 1526-1532. ISSN 0030-6002

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Abstract

Immunologic phenomena related to infections are well known to be truly heterogeneous, both regarding their etiol-ogy and the clinical picture. Overlapping symptoms and incomplete presentations are not seldom, which often con-stitute diagnostic challenge. Certain, optional complications of infectious diseases led to the creation of the focal infection theory more than a century ago, although only on the basis of assumptions derived from elusive and naive theories. However, an expanding body of evidence ever since did underline the impact of previous and persistent infections on the immunologic, metabolic and endocrine homeostasis. Besides briefly touching the well-defined dis-eases, as well as the outdated theories of this field, we aim to provide an overview of the grey zone of infection-relat-ed immunologic phenomena, the existence of which is biologically well established, however, their true significance on an individual basis remains uncertain.

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