Mustachio, Lisa Maria and Chelariu-Raicu, Anca and Szekvolgyi, Lorant and Roszik, Jason (2021) Targeting KRAS in Cancer: Promising Therapeutic Strategies. CANCERS, 13 (6). p. 1204. ISSN 2072-6694
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Abstract
The Kirsten rat sarcoma viral oncogene homolog (KRAS) is mutated in approximately 25% of all human cancers and is known to be a major player promoting and maintaining tumorigenesis through the RAS/MAPK pathway. Over the years, a large number of studies have identified strategies at different regulatory levels to tackle this ‘difficult-to-target’ oncoprotein. Yet, the most ideal strategy to overcome KRAS and its downstream effects has yet to be uncovered. This review summarizes the role of KRAS activating mutations in multiple cancer types as well as the key findings for potential strategies inhibiting its oncogenic behavior. A comprehensive analysis of the different pathways and mechanisms associated with KRAS activity in tumors will ultimately pave the way for promising future work that will identify optimum therapeutic strategies.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > Q1 Science (General) / természettudomány általában R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia |
| Depositing User: | Dr Lóránt Székvölgyi |
| Date Deposited: | 12 Sep 2022 12:02 |
| Last Modified: | 12 Sep 2022 12:02 |
| URI: | http://real.mtak.hu/id/eprint/148371 |
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