Mostafa, Isbera and Balázs, Bognár and Ferenc, Gallyas and Attila, Bényei and József, Jekő and Tamás, Kálai (2021) Syntheses and study of a pyrroline nitroxide condensed phospholene oxide and a pyrroline nitroxide with diphenylphosphino moiety. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 197 (5-6). pp. 515-517. ISSN 1042-6507
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Syntheses and study of a pyrroline nitroxide condensed phospholene oxide and a pyrroline nitroxide with diphenylphosphino moiety.pdf Restricted to Registered users only Download (1MB) |
Abstract
The reaction of a diene nitroxide precursor with dichlorophenylphosphine in a McCormac procedure afforded pyrroline nitroxide condensed phospholen oxide. Lithiation of the protected 3- bromo-pyrroline nitroxide followed by treatment with chlorodiphenylphosphine after deprotection afforded (1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)diphenylphosphine oxide, and after reduction, (1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)diphenylphosphine was realized, which was also supported by X-ray single crystal diffraction measurements. This pyrroline diphenylphosphine derivative was converted to hexadecylphosphonium salt, which was more effective antineoplastic agent than its analogue MITO-CP.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia |
Depositing User: | Dr. Tamás Kálai |
Date Deposited: | 16 Sep 2022 12:00 |
Last Modified: | 16 Sep 2022 12:00 |
URI: | http://real.mtak.hu/id/eprint/148746 |
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