Jenei, Adrienn and Dajnoki, Zsolt and Retzlerné Medgyesi, Barbara and Gáspár, Krisztián and Béke, Gabriella and Kinyó, Ágnes and Méhes, Gábor and Hendrik, Zoltán and Dinya, Tamás Ákos and Törőcsik, Dániel and Bíró, Tamás and Szegedi, Andrea and Kapitány, Anikó (2019) Apocrine Gland–Rich Skin Has a Non-Inflammatory IL-17–Related Immune Milieu, that Turns to Inflammatory IL-17–Mediated Disease in Hidradenitis Suppurativa. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139 (4). pp. 964-968. ISSN 0022-202X
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Abstract
The pathogenesis of hidradenitis suppurativa/ acne inversa (HS) is still unclear, but is likely initiated by follicular occlusion of the pilosebaceousapocrine units (Hoffman et al., 2017) in the apocrine gland-rich (AGR) skin (armpits, intramammary fold, genital groin, perianal areas, and buttocks). The outstanding role of keratinocytes in the initiation phase was also highlighted by recently described signaling pathways (Notch and mTOR signaling, IL-36 pathway) related to HS pathophysiology (Balato et al., 2018; Di Caprio et al., 2017; Scala et al., 2018). Following keratinocyte activation, proliferation and follicular occlusion, immune cell infiltration, pro-inflammatory cytokine, and chemokine and antimicrobial peptide (AMP) production resulting in severe destruction of the surrounding tissue lead to fully developed immunemediated inflammation.
| Item Type: | Article |
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| Additional Information: | Megosztott első és utolsó szerzőség Letters to the Editor Funding Agency and Grant Number: Hungarian Research Grants [NKFIH PD-112077, NKFIH K-128250]; European UnionEuropean Commission; European Regional Development FundEuropean Commission; European Social FundEuropean Social Fund (ESF); Hungarian Academy of SciencesHungarian Academy of Sciences; Ministry of Human Capacities [UNKP-18-4-DE-275]; [GINOP-2.3.2-15-2016-00050]; [EFOP-3.6.1-16-2016-00022]; [EFOP-3.6.3-VEKOP-16-2017-00009] Funding text: The publication is supported by Hungarian Research Grants (NKFIH PD-112077 and NKFIH K-128250), the GINOP-2.3.2-15-2016-00050, EFOP-3.6.1-16-2016-00022, and EFOP-3.6.3-VEKOP-16-2017-00009 projects. The project is co-financed by the European Union and the European Regional Development Fund and the European Social Fund. AK is a recipient of the Janos Bolyai research scholarship of the Hungarian Academy of Sciences and was also supported by the UNKP-18-4-DE-275 New National Excellence Program of the Ministry of Human Capacities. |
| Uncontrolled Keywords: | SKIN; T cells; ANTIMICROBIAL PEPTIDES; Chemokines; BARRIER FUNCTION; IL-17; apocrine glands; hidradenitis suppurativa; AGP, apocrine gland-poor; AGR, apocrine gland-rich; AMP, antimicrobial peptide; CCL, chemokine (C-C motif) ligand; DC, dendritic cell; HS, hidradenitis suppurativa; IHC, immunohistochemistry; |
| Subjects: | R Medicine / orvostudomány > RL Dermatology / bőrgyógyászat |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 26 Sep 2022 11:14 |
| Last Modified: | 26 Sep 2022 11:14 |
| URI: | http://real.mtak.hu/id/eprint/149834 |
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