Synergy and sensitivity-balance in concatenating experiments in NO Relaxation Delay NMR (NORD)

Timári, István and Nagy, Tamás Milán and E. Kövér, Katalin and Sørensen, Ole W. (2022) Synergy and sensitivity-balance in concatenating experiments in NO Relaxation Delay NMR (NORD). CHEMICAL COMMUNICATIONS. pp. 1-3. ISSN 1359-7345 (In Press)

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Abstract

The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}–{HSQC}–{TOCSY}, where magnetization of non-13C attached protons effectively is channeled from the TOCSY spectrum toward primarily the least sensitive spectrum of HMBC. The experiment is expected to find its place as a full-package NMR method for metabolomics, carbohydrates, peptides and small-molecules in general.

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