Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue

Gönczi, Mónika and Csemer, Andrea and Szabó, László and Sztretye, Mónika and Fodor, János and Pocsai, Krisztina and Szenthe, Kálmán and Keller-Pintér, Anikó and Köhler, Zoltán Márton and Nánási, Péter Pál and Szentandrássy, Norbert and Pál, Balázs and Csernoch, László (2022) Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (2). pp. 1-19. ISSN 1661-6596

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Astaxanthin is a lipid-soluble carotenoid influencing lipid metabolism, body weight, and insulin sensitivity. We provide a systematic analysis of acute and chronic effects of astaxanthin on different organs. Changes by chronic astaxanthin feeding were analyzed on general metabolism, expression of regulatory proteins in the skeletal muscle, as well as changes of excitation and synaptic activity in the hypothalamic arcuate nucleus of mice. Acute responses were also tested on canine cardiac muscle and different neuronal populations of the hypothalamic arcuate nucleus in mice. Dietary astaxanthin significantly increased food intake. It also increased protein levels affecting glucose metabolism and fatty acid biosynthesis in skeletal muscle. Inhibitory inputs innervating neurons of the arcuate nucleus regulating metabolism and food intake were strengthened by both acute and chronic astaxanthin treatment. Astaxanthin moderately shortened cardiac action potentials, depressed their plateau potential, and reduced the maximal rate of depolarization. Based on its complex actions on metabolism and food intake, our data support the previous findings that astaxanthin is suitable for supplementing the diet of patients with disturbances in energy homeostasis.

Item Type: Article
Subjects: R Medicine / orvostudomány > RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök
Depositing User: MTMT SWORD
Date Deposited: 28 Sep 2022 12:41
Last Modified: 28 Sep 2022 12:41

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