Turai, Péter István and Nyírő, Gábor and Borka, Katalin and Micsik, Tamás and Likó, István and Patócs, Attila Balázs and Igaz, Péter (2022) Exploratory Circular RNA Profiling in Adrenocortical Tumors. CANCERS, 14 (17). No. 4313. ISSN 2072-6694
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Abstract
The histological differential diagnosis of adrenocortical adenoma and carcinoma is difficult and requires great expertise. Measures taken towards the distinction of adrenal tumors are of paramount importance. The non-coding circular RNAs (circRNAs) were shown to be expressed in a tissue and tumor specific manner. CircRNAs are investigated as a useful adjunct to the differential diagnosis of benign and malignant tumors of several organs, but they have not been investigated in adrenocortical tumors yet. Here, we have performed circRNA profiling in adrenocortical tumors by next-generation sequencing to detect already known and de novo circRNAs. Out of the five most differentially expressed circRNAs, circPHC3 could be confirmed by TaqMan RT-qPCR to be overexpressed in carcinoma and adenoma vs. healthy tissues in an independent validation cohort.
Item Type: | Article |
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Uncontrolled Keywords: | adrenocortical carcinoma; adrenocortical adenoma; adrenal tissue; circular RNA; biomarker; expression; microRNA; RT-qPCR; next-generation sequencing |
Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 10 Oct 2022 06:27 |
Last Modified: | 10 Oct 2022 06:27 |
URI: | http://real.mtak.hu/id/eprint/151313 |
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