Exploratory Circular RNA Profiling in Adrenocortical Tumors

Turai, Péter István and Nyírő, Gábor and Borka, Katalin and Micsik, Tamás and Likó, István and Patócs, Attila Balázs and Igaz, Péter (2022) Exploratory Circular RNA Profiling in Adrenocortical Tumors. CANCERS, 14 (17). No. 4313. ISSN 2072-6694

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Abstract

The histological differential diagnosis of adrenocortical adenoma and carcinoma is difficult and requires great expertise. Measures taken towards the distinction of adrenal tumors are of paramount importance. The non-coding circular RNAs (circRNAs) were shown to be expressed in a tissue and tumor specific manner. CircRNAs are investigated as a useful adjunct to the differential diagnosis of benign and malignant tumors of several organs, but they have not been investigated in adrenocortical tumors yet. Here, we have performed circRNA profiling in adrenocortical tumors by next-generation sequencing to detect already known and de novo circRNAs. Out of the five most differentially expressed circRNAs, circPHC3 could be confirmed by TaqMan RT-qPCR to be overexpressed in carcinoma and adenoma vs. healthy tissues in an independent validation cohort.

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