In vivo measurement of intragastric pressure with a rubber balloon in the anesthetized rat.

Zádori, Zoltán S. and Gyires, Klára (2013) In vivo measurement of intragastric pressure with a rubber balloon in the anesthetized rat. In: Current Protocols in Toxicology. John Wiley and Sons, Inc., Unit 21.12..

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Abstract

The protocols described in this unit are designed to measure the intragastric pressure in anesthetized rats by a water-filled low-compliance rubber balloon. The balloon is introduced into the stomach either orally (by passing the balloon down the esophagus) or directly via a small incision of the fundus after laparotomy. The effects of both stimulatory (e.g., carbachol) and inhibitory (e.g., oxymetazoline) agents can be evaluated on the gastric tone and phasic contractions. The model allows the evaluation of dose-response curves and also the time-course of the effects. Furthermore, by combining centrally or peripherally acting agents the site of action can also be determined.

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