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Biologia Futura: Emerging antigen-specific therapies for autoimmune diseases

Sármay, Gabriella (2021) Biologia Futura: Emerging antigen-specific therapies for autoimmune diseases. Biologia Futura, 72 (1). pp. 15-24. ISSN 2676-8615 (print), 2676-8607 (online)

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Abstract

Autoimmune diseases are caused by breaking the central and/or peripheral tolerance against self, leading to uncontrolled immune response to autoantigens. The incidences of autoimmune diseases have increased significantly worldwide over the last decades; nearly 5% of the world's population is affected. The current treatments aim to reduce pain and inflammation to prevent organ damage and have a general immunosuppressive effect, but they cannot cure the disease. There is a huge unmet need for autoantigen-specific therapy, without affecting the immune response against pathogens. This goal can be achieved by targeting autoantigen-specific T or B cells and by restoring self-tolerance by inducing tolerogenic antigen-presenting cells (APC) and the development of regulatory T (Treg) cells, for example, by using autoantigenic peptides bound to nanoparticles. Transferring in vitro manipulated autologous tolerogenic APC or autologous autoantigen-specific Treg cells to patients is the promising approach to develop cellular therapeutics. Most recently, chimeric autoantibody receptor T cells have been designed to specifically deplete autoreactive B cells. Limitations of these novel autoantigen-specific therapies will also be discussed.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Depositing User: Zsolt Baráth
Date Deposited: 13 Oct 2022 12:58
Last Modified: 13 Oct 2022 13:08
URI: http://real.mtak.hu/id/eprint/151619

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