Sármay, Gabriella (2021) Biologia Futura: Emerging antigen-specific therapies for autoimmune diseases. Biologia Futura, 72 (1). pp. 15-24. ISSN 2676-8615 (print), 2676-8607 (online)
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Abstract
Autoimmune diseases are caused by breaking the central and/or peripheral tolerance against self, leading to uncontrolled immune response to autoantigens. The incidences of autoimmune diseases have increased significantly worldwide over the last decades; nearly 5% of the world's population is affected. The current treatments aim to reduce pain and inflammation to prevent organ damage and have a general immunosuppressive effect, but they cannot cure the disease. There is a huge unmet need for autoantigen-specific therapy, without affecting the immune response against pathogens. This goal can be achieved by targeting autoantigen-specific T or B cells and by restoring self-tolerance by inducing tolerogenic antigen-presenting cells (APC) and the development of regulatory T (Treg) cells, for example, by using autoantigenic peptides bound to nanoparticles. Transferring in vitro manipulated autologous tolerogenic APC or autologous autoantigen-specific Treg cells to patients is the promising approach to develop cellular therapeutics. Most recently, chimeric autoantibody receptor T cells have been designed to specifically deplete autoreactive B cells. Limitations of these novel autoantigen-specific therapies will also be discussed.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > Q1 Science (General) / természettudomány általában Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia |
Depositing User: | Zsolt Baráth |
Date Deposited: | 13 Oct 2022 12:58 |
Last Modified: | 13 Oct 2022 13:08 |
URI: | http://real.mtak.hu/id/eprint/151619 |
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