Dósa, Anna and Csizmadia, Tamás (2022) The role of K63-linked polyubiquitin in several types of autophagy. BIOLOGIA FUTURA : A QUARTERLY OF THE HUNGARIAN ACADEMY OF SCIENCES, 73 (2). pp. 137-148. ISSN 2676-8615 (print); 2676-8607 (online)
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Abstract
Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the maintenance of normal homeostasis in all eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified, based on how the cellular self material can incorporate into the lysosomal lumen. Ubiquitination, a well-known and frequently occurred posttranslational modification has essential role in all cell biological processes, thus in autophagy too. The second most common type of polyubiquitin chain is the K63-linked polyubiquitin, which strongly connects to some self-degradative mechanisms in the cells. In this review, we discuss the role of this type of polyubiquitin pattern in numerous autophagic processes.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > Q1 Science (General) / természettudomány általában Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia |
| Depositing User: | Zsolt Baráth |
| Date Deposited: | 17 Oct 2022 09:27 |
| Last Modified: | 17 Oct 2022 09:27 |
| URI: | http://real.mtak.hu/id/eprint/151807 |
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