Bors, Luca Anna and Orsolits, Barbara and Ahmed, Norah Mahnoor and Cho, Hyunsoo and Merkely, Béla Péter and Földes, Gábor (2022) SARS-CoV-2 infection in cardiovascular disease: Unmet need of stem cell models. Physiology International, 109 (3). pp. 305-316. ISSN 2498-602X
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Abstract
This review aims to summarise new approaches in SARS-CoV-2-related research in cardiology. We provide a head-to-head comparison of models, such as animal research and human pluripotent stem cells, to investigate the pathomechanisms of COVID-19 and find an efficient therapy. In vivo methods were useful for studying systemic processes of the disease; however, due to differences in animal and human biology, the clinical translation of the results remains a complex task. In vitro stem cell research makes cellular events more observable and effective for finding new drugs and therapies for COVID-19, including the use of stem cells. Furthermore, multicellular 3D organoids even make it possible to observe the effects of drugs to treat SARS-CoV-2 infection in human organ models.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| Depositing User: | László Sallai-Tóth |
| Date Deposited: | 07 Nov 2022 13:22 |
| Last Modified: | 07 Nov 2022 13:22 |
| URI: | http://real.mtak.hu/id/eprint/152992 |
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