Time frame of the extracellular vesicles release after high intensity exercise

György, Bernadett and Torma, Ferenc and Bábszky, Gergely and Jókai, Mátyás and Gombos, Zoltán and Bakonyi, Péter and Buzás, Edit I. and Pálóczi, Krisztina and Szabó, Tamás and Radák, Zsolt and Koltai, Erika (2021) Time frame of the extracellular vesicles release after high intensity exercise. MAGYAR SPORTTUDOMÁNYI SZEMLE, 22 (90). pp. 77-81. ISSN 1586-5428

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Abstract

Exercise related adaptation is systemic, however the adaptation paths are not completely discovered. Extracellular vesicles (EVs) could be involved in the communication between organs. We assumed that a single bout of anaerobic exercise increases the concentration of vesicles in the blood. The aim of this study was to investigate the effect of high intensity exercise on extracellular vesicles, which were isol - ated and analyzed from human venous blood. This method can help us understand more about the time frame and size distribution of the vesicle release into the blood circulation. Young, healthy, male volunteers (n=12) participated in our pilot study. Blood samples were collected before, right after, five and 24 hours later after the high intensity exercise and used for the separation of EVs. After differential centrifugation and size-exclusion chromatography, two different methods were used to count the amount of medium and small size EVs. Results revealed huge individual differences. It seems that 5 hrs after the exercise bout is an appropriate time point to collect EVs.

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