Andrási, Melinda and Gáspár, Attila and Kovács, Otilia and Baranyai, Zsolt and Klekner, Almos and Brücher, Ernő (2011) Determination of gadolinium-based magnetic resonance imaging contrast agents by micellar electrokinetic capillary chromatography. Electrophoresis, 32 (16). pp. 2223-8. ISSN 1522-2683
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Determination of gadolinium-based magnetic resonance imaging contrast agents by micellar electrokinetic capillary chromatography.pdf Restricted to Registered users only Download (1MB) | Request a copy |
Abstract
MEKC with DAD was applied to detect six Gd-based contrasting agents (CAs) (Gd-DTPA-BMA (Omniscan), Gd-HPDO3A (ProHance), Gd-DOTA (Dotarem), Gd-AAZTA, Gd-BOPTA (Multihance) and Gd-DTPA (Magnevist)) commonly used in MRI diagnostics. The achieved LODs ranged between 0.40 and 20 μM and the optimized method gave excellent precision, especially when two internal standards were applied (less than 0.34 RSD% for migration time). The MEKC technique made it possible to determine the CAs in urine and serum samples of patients having a therapeutic dose. Due to the SDS content of the running buffer, the serum samples can be directly injected to analyze Gd-based CAs without interference of high protein content.
Item Type: | Article |
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Uncontrolled Keywords: | Contrast agents, Gadolinium, MEKC, Serum |
Subjects: | Q Science / természettudomány > QD Chemistry / kémia |
Depositing User: | Dr. Álmos Klekner |
Date Deposited: | 07 Oct 2014 08:59 |
Last Modified: | 07 Oct 2014 08:59 |
URI: | http://real.mtak.hu/id/eprint/15893 |
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