Honfi, Dániel György and Gémes, Nikolett and Szabó, Enikő and Neuperger, Patricia and Balog, József Ágoston and Puskás, László and Szebeni, Gábor and Balog, Attila (2022) Comparison of Homologous and Heterologous Booster SARS-CoV-2 Vaccination in Autoimmune Rheumatic and Musculoskeletal Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19). ISSN 1661-6596
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Abstract
Vaccination against SARS-CoV-2 to prevent COVID-19 is highly recommended for immunocompromised patients with autoimmune rheumatic and musculoskeletal diseases (aiRMDs). Little is known about the effect of booster vaccination or infection followed by previously completed two-dose vaccination in aiRMDs. We determined neutralizing anti-SARS-CoV-2 antibody levels and applied flow cytometric immunophenotyping to quantify the SARS-CoV-2 reactive B- and T-cell mediated immunity in aiRMDs receiving homologous or heterologous boosters or acquired infection following vaccination. Patients receiving a heterologous booster had a higher proportion of IgM+ SARS-CoV-2 S+ CD19+CD27+ peripheral memory B-cells in comparison to those who acquired infection. Biologic therapy decreased the number of S+CD19+; S+CD19+CD27+IgG+; and S+CD19+CD27+IgM+ B-cells. The response rate to a booster event in cellular immunity was the highest in the S-, M-, and N-reactive CD4+CD40L+ T-cell subset. Patients with a disease duration of more than 10 years had higher proportions of CD8+TNF-α+ and CD8+IFN-γ+ T-cells in comparison to patients who were diagnosed less than 10 years ago. We detected neutralizing antibodies, S+ reactive peripheral memory B-cells, and five S-, M-, and N-reactive T-cells subsets in our patient cohort showing the importance of booster events. Biologic therapy and <10 years disease duration may confound anti-SARS-CoV-2 specific immunity in aiRMDs.
| Item Type: | Article |
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| Additional Information: | Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFIH), Hungary [2020-1.1.6-JOVO -2021-00003, 142877 FK22OTKA]; SZTE AOK-KKA Hetenyi 2020 grant; Ministry of Innovation and Technology - National Research, Development, and Innovation Fund [C1764415]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00582/22/8] Funding text: This research was funded by the grants 2020-1.1.6-JOVO -2021-00003 and 142877 FK22OTKA (GJS) from the National Research, Development, and Innovation Office (NKFIH), Hungary. This work was supported by the SZTE AOK-KKA Hetenyi 2020 grant (AB). This manuscript was prepared with the professional support of the doctoral student scholarship program of the Ministry of Innovation and Technology, financed by the National Research, Development, and Innovation Fund for NG (C1764415). This paper was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00582/22/8 for GJS). |
| Subjects: | R Medicine / orvostudomány > RZ Other systems of medicine / orvostudomány egyéb területei |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 15 Feb 2023 16:23 |
| Last Modified: | 05 Sep 2023 10:56 |
| URI: | http://real.mtak.hu/id/eprint/159136 |
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