Arteriolar biomechanics in a rat polycystic ovary syndrome model - effects of parallel vitamin D3 treatment.

Sara, L. and Nádasy, György László and Antal, Péter and Szekeres, Mária and Monori-Kiss, A. and Horváth, Eszter Mária and Tőkés, Anna-Mária and Masszi, G. and Monos, Emil and Várbíró, Szabolcs (2012) Arteriolar biomechanics in a rat polycystic ovary syndrome model - effects of parallel vitamin D3 treatment. Acta Physiologica Hungarica, 99 (3). pp. 279-288. ISSN 0231-424X, ESSN: 1588-2683

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Abstract

To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3. METHODS AND RESULTS: The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- and DHT with vitamin D3-treated animals in contracted and passive conditions. Increased wall stress and distensibility as well as increased vascular lumen were detected after DHT treatment. Concomitant vitamin D3 treatment lowered the mechanical load of the arterioles and restored the vascular diameter. CONCLUSION: The hyperandrogenic state resulted in more rigid, less flexible arteriolar walls with increased vascular lumen compared with controls. DHT treatment caused eutrophic remodelling of gracilis arteriole. These prehypertensive alterations caused by chronic DHT treatment were mostly reversed by concomitant vitamin D3 administration.

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