Inoue, Shota and Matsuura, Kyohei and Eguchi, Daisuke and Wakayama, Masahiro and Ono, Kosuke (2023) Effects of different modes and intensities of exercise on longevity proteins in middle-aged mouse skeletal muscle. PHYSIOLOGY INTERNATIONAL, 110 (2). pp. 150-159. ISSN 2498-602X
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Abstract
Physical exercise represents one of the most effective approaches to anti-aging. The goal of this study was to verify the effects of different modes and intensities of exercise on longevity proteins in the skeletal muscle in midlife. Middle-aged mice were trained in aerobic or resistance exercise for 8 weeks, and the changes in sirtuin 1 (SIRT1), adenosine monophosphate-activated kinase (AMPK), and mammalian target of rapamycin (mTOR) pathways in the skeletal muscle were evaluated by western blotting. Long-term exercise had no effects on skeletal muscle SIRT1 abundance, whereas high-intensity aerobic exercise increased AMPK phosphorylation and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Low-intensity resistance exercise facilitated Akt/mTOR/p70 ribosomal protein kinase S6 (p70S6K) signaling but did not induce muscle hypertrophy. Conversely, high-intensity resistance exercise stimulated muscle hypertrophy without phosphorylation of mTOR signaling-related proteins. These results suggest the importance of setting exercise modes and intensities for anti-aging in midlife.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QP Physiology / élettan R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 23 Jun 2023 09:50 |
Last Modified: | 12 Jun 2024 23:15 |
URI: | https://real.mtak.hu/id/eprint/168527 |
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