Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus

Márkus, Bernadett and Temesszentandrási, György and Vörös, Krisztián and Jakab, László and Fekete, Béla and Farkas, Henriette and Prohászka, Zoltán and Masszi, Tamás and Kalabay, László (2022) Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 69 (2). pp. 171-175. ISSN 1217-8950

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Abstract

Helicobacter pylori is a common pathogen causing gastric inflammation and malignancy. Fetuin-A is a multifunctional protein that is involved in the regulation of calcification, insulin resistance and inflammation. Reports on serum levels of fetuin-A in acute H. pylori infection are contradictory. We intended to see whether H. pylori post-infection status has a long-term effect on serum fetuin-A levels in a well-characterized series of systemic lupus erythematosus cases.In this cross-sectional study 117 patients with systemic lupus erythematosus were enrolled. Helicobacter infection status and serum fetuin-A concentration were determined by ELISA and radial immunodiffusion, respectively. H. pylori positive patients had higher serum fetuin-A concentration than negative ones: 517 (456-603) vs. 476 (408-544) mg L-1, median (25-75% percentiles), P = 0.020. No other parameters differed between these groups. During univariate regression analysis fetuin-A levels were associated with Erythrocyte sedimentation rate (ESR), White blood cell count (WBC), C-reactive protein (CRP), serum total protein, albumin, and the SLEDAI index at the time of diagnosis but only serum albumin remained a significant determinant in multivariate regression study.

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