Sárközy, Márta and Watzinger, Simon and Kovács, Zsuzsanna Z.A. and Acar, Eylem and Márványkövi, Fanni and Fintha, Attila and Krenács, Tibor and Pokreisz, Peter (2023) Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats. JACC: BASIC TO TRANSLATIONAL SCIENCE. ISSN 2452-302X (In Press)
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Abstract
Chronic kidney disease is a global health problem affecting 10% to 12% of the population. Uremic cardiomyopathy is often characterized by left ventricular hypertrophy, fibrosis, and diastolic dysfunction. Dysregulation of neuregulin-1β signaling in the heart is a known contributor to heart failure. The systemically administered recombinant human neuregulin-1β for 10 days in our 5/6 nephrectomy–induced model of chronic kidney disease alleviated the progression of uremic cardiomyopathy and kidney dysfunction in type 4 cardiorenal syndrome. The currently presented positive preclinical data warrant clinical studies to confirm the beneficial effects of recombinant human neuregulin-1β in patients with chronic kidney disease.
| Item Type: | Article |
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| Uncontrolled Keywords: | cardiac fibrosis, chronic kidney disease, left ventricular hypertrophy, recombinant human neuregulin-1β, uremic cardiomyopathy |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC685 Diseases of the heart, Cardiology / kardiológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 11 Aug 2023 11:26 |
| Last Modified: | 11 Aug 2023 11:26 |
| URI: | http://real.mtak.hu/id/eprint/171351 |
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