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Respiratory pathogens among ill pilgrims and the potential benefit of using point-of-care rapid molecular diagnostic tools during the Hajj

Hoang, Van-Thuan and Dao, Thi-Loi and Ly, Tran Duc Anh and Drali, Tassadit and Yezli, Saber and Parola, Philippe and De Santi, Vincent Pommier and Gautret, Philippe (2022) Respiratory pathogens among ill pilgrims and the potential benefit of using point-of-care rapid molecular diagnostic tools during the Hajj. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 69 (4). pp. 283-289. ISSN 1217-8950

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Abstract

We investigated respiratory pathogens among ill Hajj pilgrims from Marseille. We also discuss the potential role of point-of-care (POC) rapid molecular diagnostic tools for this purpose. Clinical data were collected using a standardised questionnaire. Influenza A and B viruses, human rhinovirus and human coronaviruses, Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Klebsiella pneumoniae were investigated using real-time PCR in respiratory samples obtained during travel, at the onset of symptoms. 207 participants were included. A cough, expectoration, rhinitis and a sore throat were the most frequent respiratory symptoms, followed by loss of voice and dyspnoea. 38.7% and 25.1% of pilgrims reported a fever and influenza-like symptoms, respectively. 59.4% pilgrims received antibiotics. Rhinovirus ( 40.6%) was the most frequent pathogen, followed by S. aureus (35.8%) and H. influenzae (30.4%). Virus and bacteria co-infections were identified in 28.5% of participants. 25.1% pilgrims who were positive for respiratory bacteria did not receive antibiotic treatment. In the context of the Hajj pilgrimage, it is important to detect infections that can be easily managed with appropriate treatment, and those that can affect prognosis, requiring hospitalisation. POC rapid molecular diagnostic tools could be used for patient management at small Hajj medical missions and to rationalise antibiotic consumption among Hajj pilgrims.

Item Type: Article
Additional Information: Funding Agency and Grant Number: National Research Agency [ANR-10-IAHU-03]; Region Provence Alpes Cote d'Azur; European funding FEDER PRIMI; Institut Hospitalo-Universitaire (IHU) Mediterranee Infection Funding text: This study was supported by the Institut Hospitalo-Universitaire (IHU) Mediterranee Infection, the National Research Agency under the program << Investissements d'avenir >>, reference ANR-10-IAHU-03, the Region Provence Alpes Cote d'Azur and European funding FEDER PRIMI.
Uncontrolled Keywords: BACTERIA; immunology; Respiratory Tract Infections; INFLUENZA; STREPTOCOCCUS-PNEUMONIAE; Carriage; Hajj; pilgrims; FRENCH PILGRIMS;
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 15 Aug 2023 07:03
Last Modified: 15 Aug 2023 07:03
URI: http://real.mtak.hu/id/eprint/171466

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