Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat

Singh, Akanksha and Srivastava, Parisha and Verma, Avnish Kumar and Arya, Jitendra Kumar and Rizvi, Syed Ibrahim (2023) Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat. BIOLOGIA FUTURA, 74 (1-2). pp. 221-229. ISSN 2676-8615 (print); 2676-8607 (online)

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Abstract

Curcumin, a strong natural compound with numerous health benefits, is extracted from the Curcuma longa. According to recent research findings, it also acts as a calorie restriction mimetic. We examined established aging biomarkers in eryth- rocytes and plasma and tested a persistent oral dietary dose of curcumin in young and d-galactose-induced accelerated rat aging models. For four weeks, d-gal (300 mg/kg b.w. subcutaneously) and curcumin (200 mg/kg b.w. oral) were adminis- tered simultaneously to test the protective effects of curcumin against d-galactose-induced accelerated aging and oxidative stress. In the accelerated senescent rat model, we discovered a significant rise in protein carbonyl, malonaldehyde (MDA), and advanced oxidation protein products. Increased levels of catalase, superoxide dismutase, ferric-reducing antioxidant potential, and reduced glutathione (GSH) were observed. Our findings reveal that curcumin has characteristics resembling a calorie restriction mimic and can successfully maintain redox equilibrium throughout the aging process in rat erythrocytes and plasma.

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