Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018

Benkő, Ria and Matuz, Mária and Pető, Zoltán and Weist, Klaus and Heuer, Ole and Vlahović-Palčevski, Vera and Monnet, Dominique L. and Galistiani, Githa Fungie and Salvesen Blix, Hege and Soós, Gyöngyvér and Hajdú, Edit (2022) Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018. EUROSURVEILLANCE, 27 (41). ISSN 1025-496X

Preview

Text eurosurv-27-41-2.pdf Available under License Creative Commons Attribution. Download (933kB) | Preview

Abstract

Background: In 2019, the World Health Organization published the 21st Model list of Essential Medicines and updated the Access, Watch Reserve (AWaRe) anti- biotics classification to improve metrics and indicators for antibiotic stewardship activities. Reserve antibi- otics are regarded as last-resort treatment options. Aim: We investigated hospital-sector consumption quantities and trends of Reserve group antibiotics in European Union/European Economic Area coun- tries and the United Kingdom (EU/EEA/UK). Methods: Hospital-sector antimicrobial consumption data for 2010–2018 were obtained from the European Centre for Disease Prevention and Control. Antibacterials’ consumption for systemic use (Anatomical Therapeutic Chemical classification (ATC) group J01) were included in the analysis and expressed as defined daily doses (DDD) per 1,000 inhabitants per day. We defined reserve antibiotics as per AWaRe classification and applied linear regression to analyse trends in con- sumption of reserve antibiotics throughout the study period. Results: EU/EEA/UK average hospital-sector reserve-antibiotic consumption increased from 0.017 to 0.050 DDD per 1,000 inhabitants per day over the study period (p = 0.002). This significant increase con- cerned 15 countries. In 2018, four antibiotics (tigecy- cline, colistin, linezolid and daptomycin) constituted 91% of the consumption. Both absolute and relative (% of total hospital sector) consumption of reserve anti- biotics varied considerably (up to 42-fold) between countries (from 0.004 to 0.155 DDD per 1,000 inhab- itants per day and from 0.2% to 9.3%, respectively). Conclusion: An increasing trend in reserve antibiotic consumption was found in Europe. The substantial variation between countries may reflect the burden of infection with multidrug-resistant bacteria. Our results could guide national actions or optimisation of reserve antibiotic use.

Actions (login required)

Edit Item