correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes

Nyerki, Emil and Kalmár, Tibor and Schütz, Oszkár and Lima, Rui Maria Dániel and Neparáczki, Endre and Török, Tibor and Maróti, Zoltán (2023) correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes. GENOME BIOLOGY, 24 (1). No-38. ISSN 1474-7596

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Abstract

Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×–11.9×) using samples with known family relations and known/unknown population structure. Based on our results, correctKin allows for the reliable identification of relatedness up to the 4th degree from variable/low-coverage ancient or badly degraded forensic whole genome sequencing data.

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