Visually Evoked Local Field Potential Changes in the Caudate Nucleus are Remarkably More Frequent in Awake, Behaving Cats Than in Anaesthetized Animals

Nyujtó, Diána and Kiss, Ádám and Bodosi, Balázs and Eördegh, Gabriella and Tót, Kálmán and Kelemen, András and Nagy, Attila (2024) Visually Evoked Local Field Potential Changes in the Caudate Nucleus are Remarkably More Frequent in Awake, Behaving Cats Than in Anaesthetized Animals. PHYSIOLOGY INTERNATIONAL, 111 (1). pp. 47-62. ISSN 2498-602X (print); 2677-0164 (online)

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Abstract

Previous results show that halothane gas anaesthesia has a suppressive effect on the visually evoked single-cell activities in the feline caudate nucleus (CN). In this study, we asked whether the low-frequency neuronal signals, the local field potentials (LFP) are also suppressed in the CN of anaesthetized animals. To answer this question, we compared the LFPs recorded from the CN of two halothane-anaesthetized (1.0%), paralyzed, and two awake, behaving cats during static and dynamic visual stimulation. The behaving animals were trained to perform a visual fixation task. Our results denoted a lower proportion of significant power changes to visual stimulation in the CN of the anesthetized cats in each frequency range (from delta to beta) of the LFPs, except gamma. These differences in power changes were more obvious in static visual stimulation, but still, remarkable differences were found in dynamic stimulation, too. The largest differences were found in the alpha and beta frequency bands for static stimulation. Concerning dynamic stimulation, the differences were the biggest in the theta, alpha and beta bands. Similar to the single-cell activities, remarkable differences were found between the visually evoked LFP changes in the CN of the anaesthetized, paralyzed and awake, behaving cats. The halothane gas anaesthesia and the immobilization suppressed the significant LFP power alterations in the CN to both static and dynamic stimulation. These results suggest the priority of the application of behaving animals even in the analysis of the visually evoked low-frequency electric signals, the LFPs recorded from the CN.

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