The significance of neutrophil/lympocyte ratio and platelet/lymphocyte ratio in predicting diabetic polyneuropathy and neuropathic pain severity as inflammatory factors

Terzi, Mustafa and Ethemoglu, Ozlem and Eren, Mehmet Ali and Kocatürk, Özcan (2023) The significance of neutrophil/lympocyte ratio and platelet/lymphocyte ratio in predicting diabetic polyneuropathy and neuropathic pain severity as inflammatory factors. IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE, 76 (11-12). pp. 408-414. ISSN 0019-1442

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Abstract

Background and purpose – Neuropathic pain may appear as one of the first symp- toms that take the patient to the physician in type 2 diabetes, which can be asymptomatic for years. Although it is accepted that diabe- tes is a trigger for vascular inflammation, it has been suggested that inflammation itself may trigger diabetes. In our study, we aimed to investigate the relationship between dia- betic polyneuropathy and neuropathic pain and inflammatory markers. Methods – The study included 44 healthy controls, 46 diabetic patients with normal electroneuromyography (ENMG) and 44 dia- betic patients with polyneuropathy detected in ENMG. Sedimentation, C-reactive protein (CRP), Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLO) and mean platelet volume (MPV) values were record- ed in the sera of the patients. The Douleur Neuropathic 4 (DNP4) Questions was used to evaluate the presence of neuropathic pain in the patients, and the Visual Analogue Scale (VAS) was used to evaluate the severity of pain. Results – NLR, CRP, sedimentation levels were statistically significantly higher in the DMP+ and DMP– patient groups compared to the control group. PLO and MPV levels were significantly higher in the DMP+ patient group compared to both the DMP– patient group and the control group. The means of VAS and DN4 scores were statistically significantly higher in the DMP+ patient group than in the DMP– patient group. In the DMP– patient group, the NLR levels of those with neuropathic pain according to the DN4 scale were statistically significantly higher than those without neu- ropathic pain. Conclusion – Diabetic neuropathy is one of the common complications of diabetes, affecting about half of patients. Our study shows that NLR, PLO, MPV values can be used as parameters to help us make an easy and fast diagnosis in diabetic polyneurop- athy. However, their reliability in the diag- nosis of diabetic polyneuropathy should be evaluated with studies to be conducted with larger patient and control groups.

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