Synthesis of 3,4-disubstituted pyrroline nitroxides containing diphenylphosphane or diphenylphosphane oxide substituents

Balázsi, Áron and Bognár, Balázs and Jekő, József and Kálai, Tamás (2024) Synthesis of 3,4-disubstituted pyrroline nitroxides containing diphenylphosphane or diphenylphosphane oxide substituents. SynOpen.

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Abstract

Methyl 4-(diphenylphosphoryl)-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-carboxylate-1-oxydanyl was obtained as a key intermediate of the reaction starting from 3,4-dibromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-oxydanyl or methyl 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-carboxylate-1-oxidanyl. This key compound could be converted to an azido-specifc Staudinger ligation–inducing spin label, amino– and thiol–specifc spin label, or MITO–CP–like antiproliferative agent.

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