Garza, Alejandra P. and Morton, Lorena and Pállinger, Éva and Buzás, Edit I. and Schreiber, Stefanie and Schott, Björn H. and Dunay, Ildikó Rita (2023) Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration. BRAIN BEHAVIOR IMMUNITY - HEALTH, 28. No.-100597. ISSN 2666-3546
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Abstract
Tobacco smoking is strongly linked to vascular damage contributing to the development of hypertension, atherosclerosis, as well as increasing the risk for neurodegeneration. Still, the involvement of the innate immune system in the development of vascular damage upon chronic tobacco use before the onset of clinical symptoms is not fully characterized. Our data provide evidence that a single acute exposure to tobacco elicits the secretion of extracellular vesicles expressing CD105 and CD49e from endothelial cells, granting further recognition of early preclinical biomarkers of vascular damage. Furthermore, we investigated the effects of smoking on the immune system of healthy asymptomatic chronic smokers compared to never-smokers, focusing on the innate immune system. Our data reveal a distinct immune landscape representative for early stages of vascular damage in clinically asymptomatic chronic smokers, before tobacco smoking related diseases develop. These results indicate a dysregulated immuno-vascular axis in chronic tobacco smokers that are otherwise considered as healthy individuals. The distinct alterations are characterized by increased CD36 expression by the blood monocyte subsets, neutrophilia and increased plasma IL-18 and reduced levels of IL-33, IL-10 and IL-8. Additionally, reduced levels of circulating BDNF and elevated sTREM2, which are associated with neurodegeneration, suggest a considerable impact of tobacco smoking on CNS function in clinically healthy individuals. These findings provide profound insight into the initial and ongoing effects of tobacco smoking and the potential vascular damage contributing to neurodegenerative disorders, specifically cerebrovascular dysfunction and dementia. © 2023 The Authors
| Item Type: | Article |
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| Additional Information: | Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University Magdeburg, Germany Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary HCEMM SU Extracellular Vesicle Research Group, Budapest, Hungary ELKH-SE Translational Extracellular Vesicle Research Group, Budapest, Hungary Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany Center for Behavioral Brain Sciences, Magdeburg, Germany German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany Leibniz Institute of Neurobiology, Magdeburg, Germany Department of Psychiatry and Psychotherapy, University Medicine Göttingen, Göttingen, Germany Cited By :2 Export Date: 14 November 2023 Correspondence Address: Dunay, I.R.; Institute of Inflammation and Neurodegeneration, Leipziger Straße 44, Germany; email: ildiko.dunay@med.ovgu.de Chemicals/CAS: brain derived neurotrophic factor, 218441-99-7; carboxyfluorescein, 72088-94-9; interleukin 18, 189304-55-0; interleukin 8, 114308-91-7; phycoerythrin, 11016-17-4 Tradenames: FlowJo, Tree Star; SpectraMax, Molecular Devices Manufacturers: Alexan Mack; ProteinTechMolecular Devices; Thermo; Tree Star Funding details: 739593 Funding details: TKP2020-NKA-26 Funding details: European Regional Development Fund, ERDF Funding details: Deutsche Gesellschaft für Muskelkranke, DGM, RTG2413, Sc 26/1 Funding text 1: This research was supported by DGM Sc 26/1, RTG2413 Synage. A.P.G. B.H.S. and I.R.D. further received support from the European Fund for Regional Development and the State of Saxony-Anhalt (Research Alliance “Autonomy in Old Age”). The project has also received funding from the EU's Horizon 2020 research and innovation program under grant agreement No. 739593 and by the Hungarian Thematic Excellence Program No. TKP2020-NKA-26 and the National Cardiovascular Laboratory program. Funding text 2: This research was supported by DGM Sc 26/1, RTG2413 Synage. A.P.G., B.H.S., and I.R.D. further received support from the European Fund for Regional Development and the State of Saxony-Anhalt (Research Alliance “Autonomy in Old Age”). The project has also received funding from the EU’s Horizon 2020 research and innovation program under grant agreement No. 739593 and by the Hungarian Thematic Excellence Program No. TKP2020-NKA-26 and the National Cardiovascular Laboratory program . |
| Uncontrolled Keywords: | Tobacco smoking, Innate immunity, Extracellular vesicles, Monocytes, Vascular damage, Neurodegeneration |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH426 Genetics / genetika, örökléstan R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC554 Personality disorders. Behavior problems / személyiségzavarok, viselkedési problémák |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 04 Apr 2024 09:41 |
| Last Modified: | 04 Apr 2024 09:41 |
| URI: | https://real.mtak.hu/id/eprint/191689 |
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