Balázs, Benigna and Boros, Ákos and Pankovics, Péter and Reuter, Gábor (2023) High seroprevalence of hepatitis E virus (HEV) in South Transdanubia, Hungary (2010-2022). ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 70 (2). pp. 119-125. ISSN 1217-8950
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Abstract
Hepatitis E virus (HEV) is an increasingly recognized etiological agent of acute, chronic and extrahepatic human infections with primarily zoonotic origin in Europe. Limited numbers of comprehensive population-based studies are available related to HEV seroepidemiology, especially from Central Europe.The aim of this study was to investigate the seroprevalence and trends of total and IgM antibodies against HEV in different age groups in the population of South Transdanubia, Hungary, within a thirteen years long period between the years 2010 and 2022.We retrospectively analysed the serological test results of HEV total and HEV IgM antibodies carried out by ELISA technique using Dia.Pro (Diagnostic Bioprobes, Italy) kit from serum samples collected from patients with or without hepatitis between January 1, 2010 and December 31, 2022.The number of tested samples (∑6,996 for total antibody and ∑6,582 for IgM) increased during the study period. The average HEV total and the IgM antibody seropositivities were 33% (2,307/6,996 samples) and 9.6% (642/6,582 samples), respectively, in the study population. The HEV total antibody seropositivity varied in different age groups between 3.9% (age group 1-5 years) and 58.6% (86-90 years) and showed an increasing positivity by age. At the age groups >50 years, nearly half (43%) of the population had antibodies against HEV. The HEV IgM positivity had an increasing trend of up to 13.9% in the age group 81-85 years.High HEV total and IgM antibody seroprevalence were detected in South Transdanubia, Hungary, confirming that this region is highly endemic for HEV infections in Europe.
| Item Type: | Article |
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| Additional Information: | Funding Agency and Grant Number: National Research, Development and Innovation Office (NKFI) [FK134311] Funding text: The authors would like to thank the virology laboratory workers (Gertrud Domonkos, Zsoltne Garamvoelgyi, Eva Lovas and Csilla Weber) for accurately conducting HEV serological tests related to this study. The study was supported by a grant from National Research, Development and Innovation Office (NKFI, FK134311) . |
| Uncontrolled Keywords: | ANTIBODY; human; Hungary; seroepidemiology; hepatitis E virus; HEV; age group; |
| Subjects: | Q Science / természettudomány > QR Microbiology / mikrobiológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 15 Apr 2024 07:31 |
| Last Modified: | 15 Apr 2024 07:31 |
| URI: | https://real.mtak.hu/id/eprint/192522 |
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