Reuter, Gábor and Boros, Ákos and Pankovics, Péter (2023) Molecular epidemiology and characterization of endemic, epidemic and imported hepatitis A virus (HAV) strains in Hungary (2003-2022). ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 70 (3). pp. 246-251. ISSN 1217-8950
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Abstract
Hepatitis A virus (HAV) is one of the most important etiological agents of acute viral hepatitis but comprehensive molecular epidemiological study with chrono-phylogeographical data are not available from Hungary.Between 2003 and 2022, a total of 8,307 HAV infections were registered officially in Hungary of which 400 (4.8%) HAV IgM antibody-positive serum samples were collected countrywide. HAV genomic RNA was successfully detected in 216/400 (54%) sera by RT-PCR subsequently confirmed by sequencing. The complete nucleotide sequences of VP1 region were determined in 32 representative HAV strains. Based on the sequence analysis, 150 (69.4%) strains were characterized as HAV sub-genotype IA and 66 (30.6%) as sub-genotype IB, respectively. Based on the combined epidemiological and molecular data, epidemic, endemic, and imported HAV strains were also characterized. The first two registered countrywide outbreaks started among men-sex-with men (MSM) in 2011 (sub-genotype IA) and 2021 (sub-genotype IB), the continuously circulating endemic/domestic HAV strain (sub-genotype IA) in East Hungary and the travel-related sub-genotype IB strains from Egypt should be highlighted. All HAV strains are deposited in the HAVNET database (https://www.rivm.nl/en/havnet).In this 20-year-long comprehensive molecular epidemiological study, we report the genetic characterization and geographic distribution of endemic, epidemic and imported HAV strains for the first time in Hungary with continuous co-circulation of sub-genotypes IA and IB HAV strains since 2003. These data provide basic information about the HAV situation in the country in an international context and can promote more effective national public health intervention strategies for the prevention of HAV transmissions and infections.
| Item Type: | Article |
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| Additional Information: | Funding Agency and Grant Number: National Research, Development and Innovation Office [K111615, FK134311] Funding text: The authors would like to thank the virology laboratory workers throughout the country for accurately conducting the HAV serological diagnostic tests related to this study. We would express our special thanks to dr Timea Kolozsi (Budapest) , dr Andrea Katai (Szeged) , dr Maria Vollain (Veszprem) , dr & Aacute;gnes Juhasz (Debrecen) , and Laszlone Kosztolanyi (Miskolc) for the representative sample collection. This work was financially supported by grants from the National Research, Development and Innovation Office (K111615 and FK134311) . |
| Uncontrolled Keywords: | Hungary; Genotype; Molecular Epidemiology; hepatitis A virus; sub-genotype; |
| Subjects: | Q Science / természettudomány > QR Microbiology / mikrobiológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 24 Apr 2024 10:17 |
| Last Modified: | 24 Apr 2024 10:17 |
| URI: | https://real.mtak.hu/id/eprint/193006 |
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