Intracellular distribution of serotonin in the central nervous system and in the heart of Helix pomatia

Hiripi, László and Elekes, Károly and S.-Rózsa, Katalin (1975) Intracellular distribution of serotonin in the central nervous system and in the heart of Helix pomatia. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 42. pp. 3-20. ISSN 0365-3005

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Abstract

Examination of the subcellular localization of serotonin in the nervous and heart tissue of Helix pomatia by differential and gradient centrifugation revealed that 1. In the primary fractions of the ganglion and heart homogenizates 70 per cent of 5HT is present in bound, 30 per cent in free form. In the ganglion the 5HT content of the nuclear fraction is relatively high. 2. In the nervous tissue the highest proportion of bound 5HT is contained by the dense-core vesicles of the synaptosoma. 3. 5HT is prim arily localized in th e nerve endings also in the case of the heart and mitochondria also contain 5HT in a considerable quantity. 4. In the heart 5HT is also localized in the muscle elements.

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