Analysis of the effect of iontophoretically applied serotonin and dopamine on the identified neurones of the central nervous system of Lymnaea stagnalis L.

Kiss, István (1975) Analysis of the effect of iontophoretically applied serotonin and dopamine on the identified neurones of the central nervous system of Lymnaea stagnalis L. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 42. pp. 29-42. ISSN 0365-3005

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Abstract

On some identified giant neurones of the central nervous system of Lymnaea stagnalis th e effect of 5HT and dopamine applied iontophoretically was investigated in normal as well as Na+ and Cl--free solutions. Some of the neurones were stimulated, others inhibited by 5HT and dopamine applied to the soma. In addition several cells were found which exhibited excitatory and inhibitory reaction alternately in the different preparations. In th majority of the neurones, the effect is similar to that obtained previously by perfusion, but on some of the cells it differs from the results of earlier findings. The excitatory reaction caused by 5HT is Na+-dependent in all of the neurones except one. On the neurones showing inhibitory and variable from time to time reactions the effect of 5HT realizes at such typ e of receptors, which are not blocked by the absence either of Na+ or of Cl-. It may be suggested that in the development of th is type of effect not only one ion participates but C1- and Na+ alike. It is supported also by measuring the reversal potential on these cells. The effect manifested at the dopamine receptors appeared to be Cl--dependent in th e majority of th e neurones or it may be accounted for by a combined ionic mechanism similarly to th e 5HT effect.

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