Pharmacological properties of the receptors at the heart muscle membrane of Locusta migratoria migratorioies R. F. (Insecta)

S.-Rózsa, Katalin and V.-Szőke, Ida (1975) Pharmacological properties of the receptors at the heart muscle membrane of Locusta migratoria migratorioies R. F. (Insecta). A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 42. pp. 99-113. ISSN 0365-3005

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Abstract

The effect of receptor antagonists of Ach, 5HT and GABA were studied on the membrane of the heart muscle cells of Locusta and their interactions with the transmitters. The used antagonists of cholinergic (d-tubocurarine, atropine, nicotine), serotoninergic (BOL-148, methysergide, ergometrine) and GABA-ergic (picrotoxine, bicuculline) receptors had effect on the membrane of Locusta heart. In the majority of the cases the initial excitatory or inhibitory effects turned to opposite in sign at the 5th minute of the application. Among cholinergic antagonists d-tubocurarine, atropine and nicotine abolished both the excitatory and inhibitory effects of Ach partially or completely, while mytolon was ineffective. Among the inhibitors of 5 HT receptors BOL-148 an methysergide eliminated the excitatory effect of 5HT moreover, BOL-148 turned it to inhibition but the ergometrine only partially blocked 5HT effect. Picrotoxin abolished the effect of low concentrations of GABA, however, the effect of high concentrations of GABA (10⁻⁴ M) was antagonized only by bicuculline. According to these results the receptors of the heart membrane of Locusta may be characterized with the same phycological properties as known for vertebrates, so that they may be regarded similar to each other.

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