The effect of monoamine oxidase inhibitors on the ganglionic serotonin and catecholamine levels and on the activity in the fresh water mussel (Anodonta cygnea L., Pelecypoda)

Hiripi, László and Nemcsók, János and Salánki, János (1974) The effect of monoamine oxidase inhibitors on the ganglionic serotonin and catecholamine levels and on the activity in the fresh water mussel (Anodonta cygnea L., Pelecypoda). A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 41. pp. 25-33. ISSN 0365-3005

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Abstract

The effects of five monoamine oxidase inhibitors—actomol, pargyline, nialamide, iproniazid and tranylcypromine—were investigated on the ganglionic level of serotonin, dopamine and noradrenaline as well as on the activity of the fresh water mussel Anadonta cygnea L. MAO inhibitors did not increase significantly the ganglionic monoamine level, but they influenced markedly the activity. All the inhibitors decrease the average length of the active periods while in the length of the rest periods the pargyline and iproniazid caused no decrease but increase. The frequency of the periodicity was increased and the percentual distribution of active time was decreased after treatement. It is probable that MAO inhibitors influence the level of the active pool representing only a small part of the total monoamines and its change cannot be measured in the total amine level.

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