The Na-dependence of the resting and action potential in the giant neurones of Lymnaea stagnalis L.

Kiss, István and Salánki, János (1974) The Na-dependence of the resting and action potential in the giant neurones of Lymnaea stagnalis L. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 41. pp. 35-43. ISSN 0365-3005

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Abstract

It has been established that there is a correlation between the different sensitivity of the neurones to the removal of Na+ and to TTX. Ouabain causes a depolarization in every cell, which may be resulted by a blockade of the electrogenic Na-pump. Further evidence of the existence of the electrogenic pump is the hyperpolarizing effect of Na+ injected into the cell. Ouabain blocks this hyperpolarization. Applying К+-free solution the absence of K+ did not block considerably the electrogenic Na-pump within the interval investigated. The burst activity developed in Cl⁻-free solution becomes a continuous activity under the influence of ouabain which supports the hypothesis that the electrogenic Na-pump may play a role in the development of burst activity.

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