The role of ionic environment in the potential generation of the giant neurones of Lymnaea stagnalis L.

Kiss, István and Salánki, János (1973) The role of ionic environment in the potential generation of the giant neurones of Lymnaea stagnalis L. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 40. pp. 55-71. ISSN 0365-3005

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Abstract

On changing the ionic environment of CNS of Lymnaea stagnalis it has been established that 1. On removing the Na+ the activity of several neurones ceased within a short time, while that of the other neurones ceased later. Even such a neuron was found, which continued to generate action potentials for as long as 30 min. in the absence of Na+. After the activity stopped the cells could be activated by depolarization, while only a part of the neurones was affected b y ACh under such conditions. 2. In Ca++-free solution the spontaneous activity of the cells was abolished within a relatively short time, but the activity of several cells was maintained for 15—20 min. 3. In the absence of K+ a relatively small hyperpolarization was accompanied by a decrease in the firing rate. 4. In the absence of Cl- the rhythm of activity of the cells became irregular, sometimes it assumed a bursting character. The obtained data can be accounted for partly by different changes in the ionic concentration gradients and in the permeability of the membrane, partly by an influence on the electrogenic Na+-pump.

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