The effects of local anaesthetics on the activity generation and chemical sensitivity of giant neurones

Kiss, István and Vadász, István (1973) The effects of local anaesthetics on the activity generation and chemical sensitivity of giant neurones. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 40. pp. 73-84. ISSN 0365-3005

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Abstract

Effects of lidocain and RG-1812 on the spontaneous activity and chemical sensitivity of the giant neurones of Lymnaea stagnalis were studied. Both drugs were found to inhibit the generation of action potential as well as to prevent the excitatory effect of ACh. It may be supposed that these two kinds of effect occur on separate receptors as their time- and concentration-dependence were not similar. During the inhibition of action potential the rising phase and the repolarization were simultaneously damaged, which indicated a blockade of both Na+ and K+-channel. The effect of RG-1812 differs from that of lidocain only quantitatively, it causes a smaller inhibition of the spontaneous spike generation, but has a more considerable effect on the ACh-sensitivity. The effects of the drugs on the sensitivity to serotonin have not proved to be unequivocally specific.

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