The role of monoamino oxidase in the inactivation of serotonin in the nervous system and other tissues of Anodonta cygnea L.

Hiripi, László and Salánki, János (1971) The role of monoamino oxidase in the inactivation of serotonin in the nervous system and other tissues of Anodonta cygnea L. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 38. pp. 31-38. ISSN 0365-3005

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Abstract

In the different tissues of Anodonta cygnea L. the serotonin inactivation was investigated by chromatographic and fluorometric methods and the following was found: 1. The monoamino oxidase is present in most of the examined tissues. 2. The ganglia contain the breakdown product of serotonin, i.e. the 5-hydroxyindole acetic acid, in an amount of 3.5 µg/g wet tissue. 3. The enzymatic activity of the ganglia, kidney, heart, CVc, intestine and gill homogenates was 170—23 mµmole serotonin disappeared/g wet tissue/hour. There is no activity in the adductor muscle, lymph and mantle. 4. In the homogenate of the ganglia the activity can be inhibited by actomol, but there is no inhibition by iproniazid.

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