Photodynamic effects and irreversible damage in autoactive neurons of Helix pomatia evoked by rose bengal and methylene blue exposed to visible light

Lábos, Elemér (1970) Photodynamic effects and irreversible damage in autoactive neurons of Helix pomatia evoked by rose bengal and methylene blue exposed to visible light. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 37. pp. 43-53. ISSN 0365-3005

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Abstract

Spikes of 50 autactive giant neurons situated superficially on the dorsal surface of suboesophageal ganglion of Helix pomatia were studied in the presence of 50100 µg/ml rose bengal and methylene blue in dark and visible light applying heat filter. In the presence of rose bengal, the photodynamic effect is manifesting in a long-lasting increase of frequency, slow depolarization, decrease of amplitude, membrane potential and overshoot. In the terminal phase the frequency is newly decreasing and polymorph subthreshold oscillations originating from different sources having multimodal amplitude and frequency distribution, appear or remain. The effects are irreversible. Methylene blue already in dark causes appreciable alterations of shape and frequency. In visible light the effect is more explicit. In the early phase of the influence the inhibitory phenomena may be more than before. In visible light a similar destruction takes place as in the case of rose bengal. Its effect is also irreversible. Seizure-like burst were observed in the presence of both stains.

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