Investigations on the chemical sensitivity of Insect hearts

S.-Rózsa, Katalin and V.-Szőke, Ida (1970) Investigations on the chemical sensitivity of Insect hearts. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 37. pp. 99-109. ISSN 0365-3005

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Abstract

Investigations were performed on the chemical sensitivity of the heart of Phaneroptera nana, Ephippigera ephippiger, Gryllotalpa vulgaris, Cardbus coriaceus and Leptinotarsa decemlineata. From the results of the experiments it was stated that the heartbeat of G. vulgaris was accelerated by acetylcholine (10⁻⁹M), noradrenaline (10⁻⁸M), adrenaline (10⁻⁸M), dopamine (10⁻⁸M), 5-hydroxvtryptamine (10⁻⁸M) and GABA (10⁻⁸M). Higher concentrations of these agents however, — except dopamine and 5-hydroxytryptamine inhibited the heart of G. vulgaris. In addition, increase of cardiac activity was observed with E. ephippiger, when 5-hydroxytryptamine was applied at 10⁻⁸M concentration to the heart of this insect. The hearts of P. nana, E. ephippiger, C. coriaceus and L. decemlineata were inhibited by the following biologically active agents, in all concentrations used: acetylcholine (10⁻⁸M), noradrenaline (10⁻⁸M), adrenaline (10⁻⁷M), dopamine (10⁻⁸M), isopropylnoradrenaline (10⁻⁷M), 5-hydroxytryptamine (10⁻⁸M), tryptamine (10⁻⁸M), tyramine (10⁻⁷M), GABA (10⁻⁸M), histamine (10⁻⁸MM). Of these drugs tested mytolon and nicotine had a double effect on the heart of P. nana and G. vulgaris. DCI and BOL-148 produced inhibition in both, whereas methysergide inhibited the heartbeat rate of P. nana and increased that of G. vulgaris. Analyzing the sites of action of acetylcholine, adrenaline, 5-hydroxytryptamine and GABA, it was stated that only the effect of 5HT occurs on separated receptors, while the rest of biologically active agents act on mixed receptor structures.

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