Pharmacological analysis of the spontaneous activity and transmission of impulses on the visceral ganglion of Anodonta cygnea L.

Varanka, István and Salánki, János (1970) Pharmacological analysis of the spontaneous activity and transmission of impulses on the visceral ganglion of Anodonta cygnea L. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 37. pp. 111-130. ISSN 0365-3005

Preview

Text 113_cut_MTA_TihanyiBiologiaiKutIntEvkonyve_37.pdf Download (9MB) | Preview

Abstract

From the investigations on the spontaneous activity of the visceral ganglion and on transmission of potentials evoked by mechanical stimulation of the sypho region in Anodonta cygnea it was concluded: 1) Acetylcholine in low concentrations (10⁻⁶-10⁻⁸M) increases while in higher concentrations (10⁻⁴-10⁻⁵M) inhibits both spontaneous activity and transmission of impulses. Cholinergic antagonists exert a stimulating effect, cholinesterase inhibitors, on the other hand, block the transmission of evoked potentials, which indicates the presence of a stimulatory and an inhibitory cholinergic system. 2) Adrenergic drugs inhibited only the transmission of impulses. Their role is not clear as the effect of adrenergic antagonists does not confirm the inhibitory effect of catecholamines. 3) Serotonin in low concentrations (10⁻⁶-10⁻⁸) had a stimulatory effect on burst activity but was ineffective on transmission. It may play a role in the generation of spontaneous activity. 4) Of the other substances tested, GABÄ does not seem to participate, while glutamte may be involved in the processes of transmission of the visceral ganglion. 5) Pharmacological difference is suggested between the cerebral and visceral ganglia. Detailed analysis of this difference may help to demonstrate the functional differentiation of the central nervous system in Anodonta cygnea.

Actions (login required)

Edit Item