5HTP-DOPA decarboxylase in the nervous system and other tissues of Anodonta cygnea L. (Pelecypoda)

Hiripi, László and Salánki, János (1969) 5HTP-DOPA decarboxylase in the nervous system and other tissues of Anodonta cygnea L. (Pelecypoda). A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 36. pp. 19-24. ISSN 0365-3005

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Abstract

1. 5HTP-DOPA decarboxylase activity was found in the homogenizates of the cerebral, visceral and pedal ganglia, cerebro-visceral connective, heart, gill and mantle of Anodonta cygnea L. The synthesis proved to be 4-6 times faster for dopamine than for serotonin. 2. In the nervous tissue the enzyme activity expressed in µg amine/g wet weight/hour was 50-100 for serotonin and 300—600 for dopamine while in other tissues these values remain under 10. The rates of the enzyme activity correspond more or less to the serotonin content of these tissues. Neither in the muscle nor in lymph was 5HTP-DOPA decarboxylase demonstratable. 3. 5HTP and DOPA are decarboxylated by one and the same enzyme, but the affinity of the DOPA is greater to the enzyme than that of the 5HTP. 4. Addition of pyridoxal phosphate to the homogenate increases the enzyme activity in a considerable degree.

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