Pharmacological investigations on the 5-hydroxytryptamine and noradrenaline receptors of Gastropoda (Helix pomatia L.) heart

S.-Rózsa, Katalin (1969) Pharmacological investigations on the 5-hydroxytryptamine and noradrenaline receptors of Gastropoda (Helix pomatia L.) heart. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 36. pp. 57-62. ISSN 0365-3005

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Abstract

The direct effect of nicotine, DCI, iproniazide, imidazole, α-methyl DOPA, reserpine and azide as well as their interaction with 5-hydroxytryptamine and noradrenaline were investigated on the heart of Helix pomatia L. It was found that all the drugs used increase heart activity and practically no differences were found in the threshold concentrations but their effect differ in the maximal degree of stimulation. The nicotine prevented the heart from the stimulatory effect of 5HT, while the effect of the noradrenaline decreased only in a small degree after nicotine pretreatment. On the other hand DCI eliminated the effect of the noradrenaline without changing the effect of 5HT. The effect of 5HT was potentiated by azide but the effect of the noradrenaline was decreased by this agent. Other drugs used altered the effect of 5HT and noradrenaline in the same manner. It seems justified, that in the Helix heart the receptors of 5HT and noradrenaline are isolated from each other and the catecholamine receptors do not play important roles in the realization of stimulatory effects. Reserpine was more effective than α-methyl DOPA. The inhibition of monoamine oxidase did not influence the effects caused by 5HT and noradrenaline.

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