New method for the evaluation of overlapping protonation equilibria of polyfunctional ligands : Effect of solvent on the protonation of the functional groups of corticotropine

Noszál, Béla and Burger, Kálmán (1979) New method for the evaluation of overlapping protonation equilibria of polyfunctional ligands : Effect of solvent on the protonation of the functional groups of corticotropine. ACTA CHIMICA HUNGARICA, 100 (1-4). pp. 275-288. ISSN 0231-3146

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Abstract

A method has been developed for the simultaneous determination of the protonation constants characteristic of the single functional groups and of pairs of groups forming hydrogen bonds, and of the number of hydrogen bonds in systems of overlapping protonation equilibria. The group and structural constants of the polyfunctional ligands, ACTH,_4 and ACTHj_ 32 polypeptides in 50% propylene glycol solution have been determined by the method, and from the constants conclusions are drawn concerning the interaction of the functional groups with one another and with the solvent.

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