Studies on the effect of iontophoretically applied l-glutamate on the giant nerve cells of Gastropoda (Helix and Lymnaea)

Salánki, János (1968) Studies on the effect of iontophoretically applied l-glutamate on the giant nerve cells of Gastropoda (Helix and Lymnaea). A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 35. pp. 75-81. ISSN 0365-3005

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Abstract

Following iontophoretic application of l-glutamate on the nerve cells of Helix and Lymnaea we have established: 1. Following iontophoresis from a micropipette with 1-2 µ opening the activity of a number of cells appears to be susceptible to the effect, while th at of other cells was not influenced. 2. Upon discrete glutamate application activity changes could be registered only in D-cells, in the H-cells they were not observable. The majority of D-cells responded with increased activity, their minority with a decrease of activity. 3. The selective effect observable following iontophoretic application speaks in favour of the function of glutamate as a transmitter, this effect, however, should be distinguished from the aspecific effect taking place following application of high doses of glutamate.

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